Pathology dictionary -
CD34 is a protein normally produced by the cells inside blood vessels, immune cells, and supporting cells. CD34 can also be produced by tumour cells. Pathologists use a test called immunohistochemistry to see cells producing CD34 under the microscope.
Normal types of cells that produce CD34:
Endothelial cells – These are the cells that line the inside of blood vessels throughout the body.
Hematopoietic progenitor cells – These are immature cells that will later become part of the immune system.
Fibroblasts – Fibroblasts are found all over the body. They are support cells that help hold the body together. They also help heal the body after injury.
Non-cancerous tumours that produce CD34 include:
Types of cancers that produce CD34 include:
Dermatofibrosarcoma protuberans (DFSP).
Acute myeloid leukemia.