Borderline Brenner tumour

By Jason Wasserman MD PhD FRCPC
March 6, 2023

What is a borderline Brenner tumour?

A borderline Brenner tumour is a rare non-cancerous type of ovarian tumour. The tumour starts from the cells normally found on the outside surface of the ovary. Most are believed to develop from a benign Brenner tumour.

What are the symptoms of a borderline Brenner tumour?

Most borderline Brenner tumours do not cause any symptoms until the tumour becomes very large. As a result, smaller tumours are usually found incidentally when the ovary is removed for other reasons.

What is the difference between a borderline Brenner tumour and a malignant Brenner tumour?

A borderline Brenner tumour is a non-cancerous type of tumour that will not metastasize (spread) to other parts of the body. In contrast, a malignant Brenner tumour is a type of ovarian cancer made of very abnormal-looking cells that can metastasize to other parts of the body.

How is this diagnosis made?

The diagnosis of borderline Brenner tumour can only be made after the tumour is removed and examined under the microscope by a pathologist.

What does a borderline Brenner tumour look like under the microscope?

When examined under the microscope, borderline Brenner is made up of tumour cells that look very similar to the cells normally found in the bladder. These cells are called transitional cells or urothelial cells. The tumour cells form long finger-like structures that pathologists describe as papillary. Mitotic figures (tumour cells dividing to create new tumour cells) may be found. In a borderline tumour, the cells do not show any evidence of invasion into the connective tissue.

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Benign Brenner tumour of the ovary

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