June 23, 2023
A malignant spindle cell neoplasm is a cancerous tumour made up of spindle-shaped cells, long thin cells that resemble cells normally found in connective tissue. The term malignant spindle cell neoplasm is a descriptive diagnosis used to describe a wide variety of cancer types made up of spindle-shaped cells. For example, many types of sarcomas are made up of spindle cells and these tumours are often described as malignant spindle cell neoplasms. However, some types of carcinomas can also be made up of spindle cells, in particular spindle cell squamous cell carcinoma.
This diagnosis is often used when there is not enough tissue to render a more definitive diagnosis (such as after a biopsy) or when the features do not allow the tumour to be put in a more specific diagnostic category.
Yes. A malignant spindle cell neoplasm is a cancerous tumour made up of spindle-shaped cells.
The cause of a malignant spindle cell neoplasm depends on the location of the tumour and the type of cell that gave rise to the tumour. For example, many malignant spindle cell neoplasms are a type of sarcoma and these tumours often contain genetic alterations that cause normal cells to change into cancerous cells over time. Malignant spindle cell neoplasms made up of squamous cells, however, are often caused by environmental factors such as excessive sun exposure, tobacco smoking, and alcohol abuse.
There are many types of cancers that can be classified as malignant spindle cell neoplasms due to their characteristic spindle-shaped cell morphology.
Common types of malignant spindle cell neoplasms include: