This article will help you read and understand your pathology report for neurofibroma.
by Bibianna Purgina MD FRCPC, updated December 30, 2020
Nerves are like long wires made up of groups of cells called neurons. Nerves transmit information (such as temperature, pressure, and pain) between your brain and your body. Nerves are found throughout your body. Some nerves are very small (like those just under the surface of the skin) while other are very large (like those that go to muscles).
A neurofibromas is a common non-cancerous type of tumour. It can occur at any age and in any location in the body. Patients with the genetic syndrome neurofibromatosis type 1 will develop numerous neurofibromas all over their bodies.
Patients with neurofibromatosis type 1 are also at risk of developing a cancer in one of their neurofibromas. The most common cancer to develop in patients with neurofibromatosis type 1 is a malignant peripheral nerve sheath tumour.
A pathologist may make a diagnosis of neurofibroma after a small sample of the tumour is removed in a procedure called a biopsy. Or a pathologist may make the diagnosis of neurofibroma if it is removed completely at first, without a biopsy.
Under the microscope, neurofibromas are made of spindle cells that look very similar to the cells in a normal nerve. These non-cancerous tumours are usually easy to separate from the surrounding normal tissue. Because they are attached to a nerve, these tumours can cause symptoms such as pain or tingling.