This article will help you read and understand your pathology report for seborrheic keratosis.
by Pavandeep Gill, MD and Allison Osmond, MD FRCPC, updated on May 9, 2019
Anatomy and histology of skin
Skin is made up of three layers: epidermis, dermis, and subcutaneous fat. The surface and the part you can see when you look at your skin is called the epidermis. The cells that make up the epidermis include squamous cells, basal cells, melanocytes, Merkel cells, and cells of the immune system. The squamous cells in the epidermis produce a material called keratin which makes the skin waterproof and strong and protects us from toxins and injuries.
The dermis is directly below the epidermis. The dermis is separated from the epidermis by a thin layer of tissue called the basement membrane. The dermis contains blood vessels and nerves. Below the dermis is a layer of fat called subcutaneous adipose tissue.
Seborrheic keratosis is a non-cancerous disease that involves the squamous cells in the epidermis. When viewed through a microscope, the normal epidermis is made up of several layers of squamous cells stacked one of top of another, like the bricks in a house. In this condition, there is an increased number of small, round, and flattened squamous cells.
Small spaces called cysts filled with keratin are also seen in the epidermis. Pathologists call these spaces “keratin pearls”. Your pathologist will examine your tissue sample carefully to make sure there is no sign of cancer or pre-cancerous disease.
Seborrheic keratosis is a very common condition and seen more often as people age.
Without a microscope, seborrheic keratosis may look like a raised or bumpy area of skin with a light tan or black colour. It is often described as looking as if it was “stuck on” to skin. The size of the involved skin can range from a few millimetres to a couple of centimetres and many patients have more than one. It may look similar to a wart or liver spot.
Pathologists divide seborrheic keratosis into types based on how the cells look under the microscope. Each type is called a variant.
Treatment is not usually necessary for seborrheic keratosis. They can be removed for cosmetic purposes or when the diagnosis is not clear without the help of a microscope.