This article will help you read and understand your pathology report for squamous papilloma of the oral cavity.
by Jason Wasserman MD PhD FCPCP, reviewed by our Patient Partners on November 13, 2020
– A squamous papilloma is a non-cancerous growth that develops on the inside of the mouth.
– Some squamous papillomas are caused by infection of the cells inside the mouth by human papillomavirus (HPV).
The oral cavity is the beginning of the aerodigestive tract. It is used for both breathing and taking in food. The oral cavity is a complex area of the body that is made up of many parts.
The oral cavity includes:
The surface of the oral cavity is lined by specialized squamous cells that create a barrier called the epithelium. The tissue below the epithelium is called stroma. The epithelium is separated from the stroma by a thin strip of tissue called the basement membrane. Pathologists use the word mucosa to describe all of the tissue above the stroma.
A squamous papilloma is a common type of non-cancerous growth. It starts from the epithelium lining the inside of the mouth and is made up of squamous cells that connect together to form long finger like projections of tissue. Pathologists call these finger like projections papilla and the pattern of growth papillary. Most start on the tongue, inner cheek (buccal mucosa), or roof of the mouth (hard or soft palate) although they can start any where in the mouth.
Some squamous papillomas in the mouth are caused by infection of the squamous cells by human papillomavirus (HPV). There are many types of human papilloma virus and the types that cause squamous papilloma are called low risk because they are not associated with an increased risk of developing cancer.
Most other squamous papillomas are probably caused by trauma such as accidental biting of the tongue, cheeks, or lips. Poorly fitting dentures or other oral devices can also cause this type of growth.
The diagnosis is made after the growth is removed and sent to a pathologist for examination under a microscope. Sometimes only a small sample of the papilloma will be removed in a procedure called a biopsy. In these situations, your doctor may suggest a second procedure to remove the remainder of the growth.