In a molecular pathology report, the word rearrangement refers to a change in the DNA structure within a cell. DNA is usually organized into long strands called chromosomes, each containing many genes. A rearrangement happens when a piece of a chromosome breaks off and attaches somewhere else, either on the same chromosome or another chromosome. …
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In a molecular pathology report, the word fusion refers to a specific genetic change in which two different genes that are normally separate join together. This joining creates a new, hybrid gene that produces an abnormal protein. These fusion events happen inside the cancer cells and are not something a person is born with. Because …
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This article was written for patients by pathologists. It aims to help patients understand their pathology report for supratentorial ependymoma, ZFTA fusion-positive. It includes sections on its symptoms, causes, genetic changes, diagnosis, WHO grade, and microscopic features. What is supratentorial ependymoma, ZFTA fusion–positive? Supratentorial ependymoma, ZFTA fusion-positive, is a type of brain tumour that arises …
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What is next-generation sequencing? Next-generation sequencing (NGS) is a way of finding out the order of the letters in DNA or RNA, the genetic material inside our cells. DNA and RNA are made of four different letters: A, C, G, and T for DNA, and A, C, G, and U for RNA. The order of …
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