MITF (microphthalmia-associated transcription factor) is a protein that helps regulate the development, function, and survival of certain types of cells, particularly melanocytes. Melanocytes are specialized cells found in the skin and other tissues where they produce a pigment called melanin. This pigment gives color to the skin, hair, and eyes. MITF plays a crucial role …
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What is HMB-45? HMB-45 (Human Melanoma Black-45) is an antibody that binds to a protein called gp100. This protein is expressed in cells called melanocytes and tumours made up of melanocytes, including melanoma. How is HMB-45 used in pathology? HMB-45 staining is commonly used by pathologists to aid in the diagnosis and classification of tumors …
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Melanocytes are a type of cell found in the skin and other body parts. These cells produce melanin, the pigment that gives colour to your skin, hair, and eyes. Melanocytes play an important role in protecting your skin from the harmful effects of ultraviolet (UV) radiation. What is their function? The primary function of melanocytes …
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A congenital nevus is a common, non-cancerous skin tumour made up of melanocytes, cells responsible for producing melanin, the pigment that gives skin its colour. Congenital nevi (the plural of nevus) are usually present at birth or develop within the first year of life, which is why they are called “congenital.” Another name for this …
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Lentigo maligna is a type of melanoma in situ, which means it is a very early stage of skin cancer that has not yet spread beyond the top layer of the skin (the epidermis). It typically develops in areas of the skin that have been exposed to the sun for many years, such as the …
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Melanoma is a type of cancer that starts in cells called melanocytes. These cells are found in the skin and produce melanin, a pigment that gives your skin its color. Melanocytes are also found in mucosal tissues, such as the lining of the mouth, nose, and rectum. Melanoma occurs when these cells grow out of …
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