In a molecular pathology report, the word rearrangement refers to a change in the DNA structure within a cell. DNA is usually organized into long strands called chromosomes, each containing many genes. A rearrangement happens when a piece of a chromosome breaks off and attaches somewhere else, either on the same chromosome or another chromosome. …
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Diffuse large B cell lymphoma (DLBCL) with MYC and BCL2 rearrangements is a type of cancer affecting B cells, a white blood cell that helps protect the body from infections. In this condition, the cancer cells grow and spread quickly. The term “diffuse” refers to how the cancer cells spread out and replace normal tissue. In this …
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What is next-generation sequencing? Next-generation sequencing (NGS) is a way of finding out the order of the letters in DNA or RNA, the genetic material inside our cells. DNA and RNA are made of four different letters: A, C, G, and T for DNA, and A, C, G, and U for RNA. The order of …
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