S100 is a protein that is made by many different types of normal, healthy cells including cells in the skin, salivary glands, fat, cartilage, and nerves. Tumours that start from these types of tissue may also make S100. Once the S100 protein is made, it is held in both the nucleus and cytoplasm of the …
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Fluorescence in situ hybridization (FISH)

Fluorescence in situ hybridization (FISH) is a laboratory test used in pathology to detect and localize the presence or absence of specific DNA sequences on chromosomes. It works by using fluorescent probes that bind to only those parts of the chromosome that match or are complementary to the probe. It is commonly used in the …
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Immunohistochemistry (IHC)

Immunohistochemistry (IHC) is a widely used laboratory test that involves the use of antibodies to detect specific antigens (proteins) in cells within tissue sections. Pathologists use this test to see the distribution and localization of specific proteins within different parts of a tissue, thereby providing valuable diagnostic, prognostic, and predictive information. How does immunohistochemistry work? …
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