What is S100? S100 is a specialized protein that is made by many different types of normal, healthy cells including cells in the skin, salivary glands, fat, cartilage, and nerves. Tumours that start from these types of tissue may also make S100. Once the S100 protein is made, it is held in both the nucleus …
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Fluorescence in situ hybridization (FISH)

What is fluorescence in situ hybridization? Fluorescence in situ hybridization (FISH) is a molecular test pathologists perform to learn more about the genetic material in a cell. FISH is commonly used to look for genetic changes in tumours. How does fluorescence in situ hybridization work? Fluorescence in situ hybridization uses a fluorescent probe which has …
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Immunohistochemistry (IHC)

What is immunohistochemistry? Immunohistochemistry (IHC) is a special test that pathologists perform on a tissue sample to help them make the correct diagnosis. This test allows pathologists to highlight groups of cells based on the chemicals those cells are making. Immunohistochemistry is usually performed on tissue after the more common H&E stain has been performed. …
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