ستمبر 22، 2023
GATA-3 (GATA binding protein 3) is a transcription factor that plays an important role in the development and differentiation of various cells within the body. It is part of the GATA family of transcription factors, which bind to specific DNA sequences in the promoter regions of target genes to regulate their expression. GATA-3 is particularly important in the development of ٹی خلیات and is a key regulator in the immune system, influencing the development of the Th2 (T helper 2) cell lineage, which is involved in the immune response to parasites and allergic reactions.
In pathology and diagnostic امیونو ہسٹو کیمسٹری (IHC), GATA-3 expression is used as a biomarker for certain types of cancers. It is notably expressed in:
The detection of GATA-3 expression can help pathologists differentiate between various tumor types and can support the identification of the primary site of tumors, especially in cases of میٹاسیٹک cancer where the origin is unknown.
GATA-3 is normally expressed in a variety of cell types and tissues, reflecting its importance in different physiological processes, including development and immune function. The primary cells and tissues that express GATA-3 include:
GATA-3 is expressed by tumors that arise in the skin, salivary glands, female reproductive tract, kidney, and urinary tract. Some tumours that arise from the peripheral nervous system also express this protein.
GATA-3 ظاہر کرنے والے ٹیومر کی کچھ مثالیں شامل ہیں:
Pathologists test for GATA-3 expression in tissue samples primarily through امیونو ہسٹو کیمسٹری (IHC), a technique that utilizes antibodies to detect specific antigens (proteins) within cells of a tissue section. Positive GATA-3 staining is typically observed as a nuclear (and sometimes cytoplasmic) expression. The intensity and distribution of staining help in the diagnosis and classification of various diseases, including identifying the origin of metastatic tumors or confirming the diagnosis of specific types of cancers, such as breast cancer and bladder cancer.
ڈاکٹروں نے یہ مضمون آپ کی پیتھالوجی رپورٹ کو پڑھنے اور سمجھنے میں آپ کی مدد کے لیے لکھا ہے۔ ہم سے رابطہ کریں اگر آپ کے پاس اس مضمون یا اپنی پیتھالوجی رپورٹ کے بارے میں سوالات ہیں۔ اپنی پیتھالوجی رپورٹ کے مکمل تعارف کے لیے، پڑھیں اس مضمون.