I-Fibrosis

August 29, 2023

I-Fibrosis yinqubo ye-pathological ebonakala ngokunqwabelana ngokweqile kwezicubu ezixhumene ne-fibrous esithweni noma esithweni. Le nqubo iyingxenye yendlela yokwelapha yemvelo yomzimba, ngokuvamile eqalwa ngenxa yokulimala noma ukulimala, okuhlanganisa ukuvuvukala okungapheli. Kodwa-ke, lapho i-fibrosis iba ngokweqile, ingaholela ekulimazeni okukhulu kwesitho esithintekile kanye nokusebenza, njengoba izicubu ezijwayelekile zithathelwa indawo yizicubu ezibaziyo.

Izinkinga ezivamile ze-fibrosis

I-Fibrosis ingavela ngenxa yezizathu ezihlukahlukene, kuhlanganise:

• Izinqubo zokuvuvukala okungapheli: Izifo ezidala isikhathi eside ukuvuvukala emzimbeni, njenge-hepatitis engapheli (ukuvuvukala kwesibindi) noma izifo zamathumbu ezivuthayo, zingaholela ku-fibrosis ezithweni ezithintekile.
• Ukutheleleka: Izifo ezithile zingabangela ukuvuvukala isikhathi eside kanye ne-fibrosis elandelayo, njenge sofuba.
• I-Autoimmune disorders: Izifo lapho amasosha omzimba ehlasela izicubu zawo, njenge-rheumatoid arthritis noma i-systemic lupus erythematosus, zingaholela ekwakhekeni kwezicubu ze-fibrotic.
• Ukulimala ngokomzimba noma ukuhlukumezeka: Amanxeba, ukusikwa ngokuhlinzwa, nezinye izinhlobo zokuhlukumezeka ngokomzimba kungaqala inqubo yokuphulukisa i-fibrotic.
• Ukuchayeka kubuthi noma izinto ezicasulayo: Ukuchayeka okungamahlalakhona ezintweni eziyingozi, okuhlanganisa izidakamizwa ezithile, amakhemikhali, nokungcola kwemvelo, kungabangela i-fibrosis ezithweni ezifana namaphaphu nesibindi.
• Ukwelashwa ngemisebe: Ukwelashwa komdlavuza okubandakanya imisebe kungalimaza izicubu futhi kuholele ku-fibrosis njengomphumela ongemuhle.

Ukubonakala kwe-Microscopic ye-fibrosis

Ngaphansi kwe-microscope, i-fibrosis ibonakala ngokuba khona kwe-collagen eyeqile nezinye izakhi ze-matrix ezingaphandle kwezicubu ezakha izicubu ze-fibrous. Lesi sicubu sibonakala siminyene futhi sakhiwe kunezicubu ezizungezile ezijwayelekile, nge ama-fibroblasts (amaseli akhiqiza izicubu ezine-fibrous) ngokuvamile abonakala ngaphakathi kwe-matrix. Ezingxenyeni zezicubu ezinamabala, izindawo ze-fibrotic zingase zibonakale njengamabhande noma ama-patches of pink (eosinophilic) ngenxa yokuba khona kwe-collagen, ephikisana nokubukeka kwezicubu ezizungezile.

Izinga nephethini ye-fibrosis ingahluka kuye ngokuthi imbangela kanye nesitho esihilelekile. Isibonelo, esibindini, i-fibrosis ingase yethule njengokuvala i-fibrosis exhuma ama-lobules angomakhelwane noma amapheshana engosi, kuyilapho isemaphashini, ingase ibonakale njengokujiya kwezindonga ze-alveolar. I-Fibrosis ingaphazamisa ukwakheka kwezicubu ezithintekile, okuholela ekulimazeni kokusebenza, njengoba izicubu eziqinile ze-fibrous zingakwazi ukwenza imisebenzi evamile yamaseli okuqala.

Mayelana nalesi sihloko

Odokotela babhale lesi sihloko ukuze bakusize ufunde futhi uqonde umbiko wakho we-pathology. Xhumana nathi uma unemibuzo mayelana nalesi sihloko noma umbiko wakho we-pathology. Ukuze uthole isingeniso esiphelele sombiko wakho we-pathology, funda lesi sihloko.

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