I-Thrombotic microangiopathy (TMA)

nguRosemarie Tremblay-LeMay MD FRCPC
January 2, 2024


I-Thrombotic microangiopathy (TMA) yiqembu lezimo lapho amaseli abomvu egazi (RBCs) zibhujiswa ngamahlule egazi emithanjeni yegazi emincane njengama-capillaries nama-arterioles. I-TMA iphinde ihlotshaniswe nokuncipha kwamaplatelet nokulimala kwezitho.

Izifo kuleli qembu zihlanganisa:

  • I-Disseminated intravascular coagulation (DIC)
  • I-Thrombotic thrombocytopenic purpura (TTP)
  • I-Hemolytic uremic syndrome (HUS)
  • I-TMA eyenzeka ngemva kokufakelwa komnkantsha

Yini ebangela i-thrombotic microangiopathy?

I-TMA ibangelwa ukwakheka okungalawuleki kwamahlule egazi amancane emithanjeni yegazi emincane. Lawa mahlule egazi abizwa ngokuthi i-thrombi. Amahlule egazi avimba ingaphakathi lomthambo wegazi futhi alimaze noma abulale ama-RBC njengoba ezama ukudlula. Izazi zezifo zichaza le nqubo njenge-hemolysis engeyona eyamasosha omzimba ngoba amasosha omzimba awabandakanyi ekulimazeni ama-RBC. Izimo ezingase ziholele ekwakhekeni okungalawuleki kwamahlule egazi kanye ne-TMA zihlanganisa izifo, umdlavuza, izinhlobo ezithile zemithi, ukukhulelwa, ukufakelwa kwezitho zomzimba, noma ukuhlukumezeka.

I-Non-Immune hemolysis

Odokotela bayihlola kanjani i-thrombotic microangiopathy?

Udokotela wakho uzokwenza ukuhlolwa kwegazi ukuze abheke izinto ezikhishwe kuma-RBC alimele njenge-bilirubin engaqondile ne-LDH. Kuzoba nokwehla kwe-haptoglobin. Kuya ohlotsheni lokuhlolwa kwe-TMA okulinganisa izinto ezihilelekile ekwakhekeni kwehlule le-blot nakho kungase kube okungavamile. Okunye ukuhlola kungasiza ekuboneni ukuthi ezinye izitho azithintekile yini, njengezinso.

Ibukeka kanjani i-thrombotic microangiopathy ngaphansi kwesibonakhulu?

Uma isampula legazi lihlolwa ngaphansi kwesibonakhulu, izingcezu ezincane zama-RBC alimele, noma ama-schistocyte, angabonakala. Kuzophinde kube nenani elikhulayo lama-RBC angavuthiwe kanye nenani elinciphile lamaplatelet.

Ama-Schistocyte

Mayelana nalesi sihloko

Lesi sihloko sabhalwa odokotela ukuze bakusize ufunde futhi uqonde umbiko wakho we-pathology. Xhumana nathi uma unemibuzo mayelana nalesi sihloko noma umbiko wakho we-pathology. Funda lesi sihloko ukuze uthole isingeniso esijwayelekile ezingxenyeni zombiko we-pathology ojwayelekile.

Ezinye izinsiza eziwusizo

I-atlas ye-Pathology
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