nucleus

Umbiko we-MyPathology
August 25, 2023

Iyini i-nucleus?

Inucleus (multiple = nuclei) ingxenye yeseli equkethe iningi lezakhi zakho zofuzo (DNA). I-nucleus itholakala ngaphakathi kwe- icyoplasm kweseli. Inhlanganisela ye-DNA namanye amaprotheni angumsizi atholakala ngaphakathi kwe-nucleus ibizwa ngokuthi i-chromatin. Iqoqo elikhulu eliyindilinga le-chromatin libizwa ngokuthi a i-nucleolus (amaningi = ama-nucleoli). I-nucleus izungezwe isithiyo esincane esibizwa ngokuthi i-nucleus membrane.

Izazi zezifo ziyihlola kanjani i-nucleus engqamuzaneni?

Kubizwe odayi ababili i-hematoxylin ne-eosin (H&E) zengezwa kusampula yethishu ngaphambi kokuba ihlolwe ngesibonakhulu. I-hematoxylin ingena ku-nucleus eyinika umbala onsomi noma oluhlaza okwesibhakabhaka. Emangqamuzaneni amaningi, i-nucleus inomumo oyisiyingi noma oval.

Izinguquko ku-nucleus empilweni nasezifo

Ukubukeka kwe-nucleus lapho kuhlolwa ngesibonakhulu kungatshela isazi sezifo eziningi mayelana nokuziphatha kwengqamuzana. Isibonelo, amaseli asebenza kakhulu angase ahlanganise izakhi zawo zofuzo zibe amabhola ayindilinga abizwa ngokuthi i-nucleoli okungabonakala ngaphakathi kwe-nucleus. Amaseli omdlavuza nawo athambekele ekusebenziseni izakhi zawo zofuzo ngaphezu kwamaseli avamile okwenza i-nucleus yawo ibe mnyama futhi ibe mkhulu. Odokotela bezifo babiza ama-dark nuclei hyperchromatic. Kumaseli angenawo umdlavuza, ulwelwesi lwenuzi luvamise ukuba bushelelezi futhi luyindilinga. Emangqamuzaneni omdlavuza, nokho, i-nucleus ilahlekelwa isimo sayo esiyindilinga futhi ukugoqa kungabonakala kulwelwesi lwenuzi. Izazi zezifo zichaza lezi zinguquko njengokungahambi kahle kolwelwesi lwenuzi.

Ubukhulu nokuma kwe-nucleus nakho kungashintshwa ngamagciwane nemisebe, kokubili okwenza i-nucleus ibe nkulu kakhulu kunokujwayelekile. Umphumela we-Viral cytopathic igama elithi pathologists elisetshenziswa ukuchaza i-nucleus engavamile kuseli elithelelwe igciwane.