Inkomba yokulebula ye-Ki-67

Inkomba yelebula ye-Ki-67 (LI) iwukuhlola okusetshenziselwa ukugula ukuze kukale ukuthi amaseli esampula yethishu ahlukana noma akhula ngokushesha kangakanani. Kuyasiza ekuqondeni ukuthi amaseli athile asebenza, noma anolaka kangakanani, ikakhulukazi kumathumba.

Iyini i-Ki-67?

Ki-67 iphrotheni etholakala ku nucleus yamaseli, okuyisikhungo sokulawula ngaphakathi kweseli ngalinye. Le phrotheni ivela lapho amaseli elungiselela ukuhlukanisa nokudala amaseli amasha, inqubo eyaziwa ngokuthi i-mitosis noma ukuhlukaniswa kwamaseli. Le phrotheni ayikho kumaseli aphumule - lawo angekho ohlelweni lokuhlukanisa. Odokotela bezifo benza ukuhlolwa okubizwa ngokuthi i-immunohistochemistry (IHC) ukubona amaseli eveza le phrotheni (lawa maseli abizwa ngokuthi i-positive noma i-reactive). Ngokulinganisa amazinga e-Ki-67, izazi zezifo zingakala ukuthi amaseli ahlukana kangakanani, anikeze imininingwane mayelana nokuziphatha kokukhula kwezicubu, ikakhulukazi ezimila.

Kungani kusetshenziswa inkomba yokulebula ye-Ki-67 ku-pathology?

Le nkomba isetshenziselwa ukusiza ama-pathologists ukuthi aqonde uhlobo lwesimila. Inikeza ulwazi olubalulekile mayelana nezinga lokukhula kwamangqamuzana ethumba, okubalulekile ekuxilongweni nasekuhleleni ukwelashwa.

Inkomba yokulebula ye-Ki-67 imtshelani udokotela wezifo?

Inkomba yokulebula ye-Ki-67 itshela udokotela wezifo ukuthi mangaki amaseli kusampula asendleleni yokuhlukana. Amaphesenti aphezulu asho ukuthi amaseli amaningi ayahlukana futhi ayakhula. Lolu lwazi lungabonisa ukuthi isimila sinolaka kangakanani.

Yini ethathwa njengenkomba yokulebula evamile noma ephezulu ye-Ki-67?

Incazelo yenkomba yelebula “evamile” noma “ephezulu” ye-Ki-67 ingahluka kuye ngohlobo lwethishu kanye nohlobo oluthile lomdlavuza oluhlolwayo. Ngokuvamile, inkomba ephansi ye-Ki-67 (iphesenti elincane lamaseli abonisa i-Ki-67) iphakamisa ukukhula kwamangqamuzana okuhamba kancane, okuvame ukubonakala esicutshini esinempilo, esivamile kanye nezimila ezinolaka olungatheni. Ngokuphambene, inkomba ephakeme ye-Ki-67 (iphesenti elikhulu lamaseli abonisa i-Ki-67) ibonisa ukukhula kwamangqamuzana okusheshayo, okungahlotshaniswa nezimila ezinolaka kakhulu. Amanani athile anqunyiwe alokho okubhekwa njengokuphakeme noma okuvamile angahluka ngokusekelwe ohlotsheni lomdlavuza futhi anqunywa ngeziqondiso zomtholampilo nocwaningo.

Ingabe inkomba ephezulu yokulebula i-Ki-67 isho umdlavuza?

Inkomba ephezulu yokulebula i-Ki-67 ikhombisa ukukhula ngokushesha kwamangqamuzana, okuyisici sezinhlobo eziningi zomdlavuza. Nokho, ayiwuhlohli umdlavuza ngokuqinisekile. Ezinye izici nokuhlolwa nakho kuyacatshangelwa ukuze kutholakale ukuxilongwa okuphelele.

Sebenzisa ezinhlotsheni ezahlukene zomdlavuza

Inkomba yokulebula ye-Ki-67 iwusizo ikakhulukazi kumdlavuza othile njengomdlavuza webele, umdlavuza wobuchopho, nama-lymphomas. Kuyasiza ekunqumeni i-prognosis (inkambo engenzeka yesifo) nokubikezela ukuthi umdlavuza ungasabela kanjani ekwelashweni.

Mayelana nalesi sihloko

Lesi sihloko sabhalwa odokotela ukuze bakusize ufunde futhi uqonde umbiko wakho we-pathology. Xhumana nathi uma unemibuzo mayelana nalesi sihloko noma umbiko wakho we-pathology. Ukuze uthole isingeniso esiphelele sombiko wakho we-pathology, funda lesi sihloko.

Izihloko ezihlobene

Umfanekiso weMitotic

Umfanekiso we-Atypical we-mitotic

Mitosis

Ezinye izinsiza eziwusizo

I-atlas ye-pathology