p16

Umbiko we-MyPathology
November 14, 2023

I-p16 iphrotheni eyenziwe ngamaseli avamile kuwo wonke umzimba. Ingenziwa futhi ngamaseli angajwayelekile okuhlanganisa nezinhlobo ezithile zomdlavuza. Iwuhlobo lwamaprotheni olubizwa ngokuthi i-tumor suppressor. Lokhu kusho ukuthi indima evamile yaleli phrotheni ukumisa ingqamuzana ekushintsheni libe ingqamuzana lomdlavuza.

Ngemva kokwenziwa, iningi le-p16 lihlala engxenyeni yeseli ebizwa ngokuthi nucleus. I-nucleus iyingxenye yengqamuzana ephethe ulwazi lwethu lofuzo oluningi. Ama-pathologists asebenzisa ukuhlolwa okubizwa ngokuthi i-immunohistochemistry (IHC) ukubona p16 ngaphakathi kwamaseli. Imiphumela yalokhu kuhlolwa isetshenziswa nolunye ulwazi ukwenza ukuxilongwa.

Kwezinye izindawo zomzimba, u-p16 uthathwa njengomaka 'obambele' i-human papillomavirus (HPV) ngoba amangqamuzana angenwe yileli gciwane akhiqiza inani elikhulu lale phrotheni. Izimila eziyingozi nezinomdlavuza ezihambisana ne-HPV njenge i-high grade squamous intraepithelial lesion (HSIL) futhi i-squamous cell carcinoma ngokuvamile i-overexpress p16 kanye nezazi zezifo zivame ukwenza I-IHC ukuze p16 isize ukuqinisekisa ukuxilongwa.

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Lesi sihloko sabhalwa odokotela ukuze bakusize ufunde futhi uqonde umbiko wakho we-pathology. Xhumana nathi uma unemibuzo mayelana nalesi sihloko noma umbiko wakho we-pathology. Ukuze uthole isingeniso esiphelele sombiko wakho we-pathology, funda lesi sihloko.

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