I-Syndrome

Umbiko we-MyPathology
October 23, 2023

I-syndrome yiqembu lezimpawu noma imiphumela yokuhlolwa konke okubangelwa isimo esiyisisekelo esifanayo noma isifo. I-syndrome ingase ibe nesizathu esisodwa, isibonelo, ukuguqulwa kofuzo, noma ingaba nezimbangela eziningana eziholela eqenjini elifanayo lezimpawu.

Kunezinhlobo eziningi ezahlukene zama-syndromes. Ama-pathologists angenza izivivinyo ezifana i-immunohistochemistry or ukulandelana kwesizukulwane esilandelayo (NGS) ukunquma ukuthi isiguli sisengozini yokuba ne-syndrome.

I-syndromes evamile ihlanganisa:

• I-Lynch syndrome - Iziguli ezinalesi sifo zisengozini enkulu yokuthola umdlavuza wekoloni nowe-endometrial.
• I-neurofibromatosis - Iziguli ezinalesi sifo zisengozini enkulu yokuthola izimila ezingenawo umdlavuza ezibizwa i-neurofibromas nezimila ezinomdlavuza ezibizwa izimila ze-peripheral nerve sheath tumors (MPNST).
• I-Tuberous sclerosis - Iziguli ezinalesi sifo zisengozini enkulu yokuba nezimila zobuchopho, izinso namaphaphu.
• UVon Hippel-Lindau - Iziguli ezinalesi sifo zisengozini enkulu yokuthola izinhlobo eziningi zamathumba okuhlanganisa nohlobo lomdlavuza wezinso olubizwa sula i-renal cell carcinoma, isimila somkhumbi wegazi okuthiwa i-hemangioblastoma, kanye nesimila se-adrenal gland esibizwa pheochromocytoma.