I-Spindle cell lipoma

ngu-Bibianna Purgina, MD FRCPC
October 6, 2022

Iyini i-spindle cell lipoma?

I-spindle cell lipoma isimila esingenawo umdlavuza esakhiwe ngamafutha futhi side, sizacile amaseli okuphotha. Lesi simila ngokuvamile siqala emhlane nasentanyeni engenhla kodwa singatholakala cishe noma kuphi emzimbeni. Iningi likhula ngaphansi kwesikhumba sethu lapho lizwakala khona njengesigaxa esithambile. Elinye igama lalesi simila yi-a i-pleomorphic lipoma.

Yiziphi izimpawu ze-spindle cell lipoma?

Iningi lama-spindle cell lipomas akhula kancane futhi abangela izimpawu ezimbalwa kakhulu. Izimila ezinkulu emhlane zingabangela ubuhlungu obubangelwa ukucindezela.

Yini ebangela i-spindle cell lipoma?

Okwamanje odokotela abazi ukuthi yini ebangela i-spindle cell lipoma.

Ukuxilongwa kwe-spindle cell lipoma kwenziwa kanjani?

Ukuxilongwa kwenziwa ngemva kokuba ingxenye noma sonke isimila sisusiwe futhi sithunyelwe kudokotela wezifo ukuze sihlolwe ngaphansi kwesibonakhulu.

I-spindle cell lipoma ibukeka kanjani ngaphansi kwe-microscope?

Lapho sihlolwa ngesibonakhulu, isimila sakhiwe inhlanganisela yama-adipocyte (amangqamuzana amafutha) namade, azacile. amaseli okuphotha. Ama-adipocyte ku-spindle cell lipoma abukeka acishe afane nama-adipocyte avamile atholakala emafutheni kuwo wonke umzimba. Kodwa-ke, ku-spindle cell lipoma, ama-adipocyte azungezwe amaseli okuphotha. I i-stroma noma izicubu ezixhumeneyo ezibambe isimila ndawonye ngokuvamile zibukeka zibomvana kakhulu ngaphansi kwesibonakhulu.

Yiziphi ezinye izivivinyo ezingenziwa ukuze kuqinisekiswe ukuxilongwa?

Odokotela bakho bezifo bangase benze izivivinyo ezengeziwe kuhlanganise i-immunohistochemistry futhi I-fluorescence in situ hybridization (INHLANZI) ukuqinisekisa ukuxilongwa kanye nokukhipha ezinye izimila ezingabukeka njenge-spindle cell lipoma.

Immunohistochemistry

Immunohistochemistry ukuhlola okuvumela izazi zezifo ukuthi zibone izinhlobo ezithile zamakhemikhali njengamaprotheni angaphakathi kwamaseli. Uma lokhu kuhlolwa kwenziwa, amaseli wesimila ku-spindle cell lipoma avamise ukuba positive (reactive) for S100 futhi I-CD34.

I-Fluorescence in situ hybridization (INHLANZI) ye-MDM2

I-MDM2 iwufuzo olukhuthaza ukuhlukana kwamaseli (ukwakhiwa kwamaseli amasha). Amaseli avamile nalawo aku-spindle cell lipomas anamakhophi amabili ofuzo lwe-MDM2. Ngokuphambene, amanye ama-cancer abukeka njengama-spindle cell lipomas anamakhophi angaphezu kwamabili ofuzo lwe-MDM2.

I-Fluorescence in situ hybridization (INHLANZI) ukuhlola okuvumela izazi zezifo ukubala inani lamakhophi ofuzo kuseli. Inombolo evamile yekhophi noma isilinganiso esivamile se-MDM2 kufuzo lokulawula njenge-CEP12 iqinisekisa ukuthi isimila siyi-spindle cell lipoma engenawo umdlavuza.