I-Mitotically active cell fibroma ye-ovary

NguJason Wasserman MD PhD FRCPC
June 7, 2023

Iyini i-mitotically active cellular fibroma?

I-mitotically active cellular fibroma wuhlobo olungenawo umdlavuza lwethumba lesibeletho. Iqala kusuka kumaseli e-stromal ngokuvamile atholakala ngaphakathi kwe-ovary. Lezi zimila zingahluka ngosayizi ukusuka ngaphansi kuka-1.0 cm ukuya ngaphezulu kuka-20 cm. Ibizwa ngokuthi 'i-mitotically active cell' fibroma ngenxa yenombolo ye izibalo ze-mitotic (ukuhlukanisa amaseli wesimila) kanye nokuminyana kwamaseli isimila (inani lamaseli isimila endaweni enikeziwe) kuphezulu uma kuqhathaniswa navamile i-ovarian fibroma.

Yiziphi izimpawu ze-mitotically active cellular fibroma?

Izimila ezincane ngokuvamile azibangeli noma yiziphi izimpawu zingatholakala ngengozi lapho ukuthwebula isithombe se-pelvis kwenziwa ngezinye izizathu. Ama-fibromas amaselula amakhulu asebenzayo angabangela izimpawu ezinjengobuhlungu noma ukucindezela kwesisu.

Izazi ze-pathologist zikwenza kanjani ukuxilonga kwe-mitotically active cell fibroma?

Ukuxilongwa kwe-mitotically active cellular fibroma ngokuvamile kwenziwa ngemva kokuba i-ovary yonke isusiwe ngokuhlinzwa futhi ithunyelwe kudokotela wezifo ukuze ihlolwe ngaphansi kwesibonakhulu.

Ibukeka kanjani i-mitotically active cellular fibroma uma ibukwa ngaphansi kwesibonakhulu?

Nge-Microscopically, isimila sakhiwe amangqamuzana amade amancane abizwa ngokuthi amaseli okuphotha. Amaseli okuphotha ngokuvamile ahlelwa ngamaqembu amagatsha abizwa ngokuthi ama-fascicles futhi azungezwe izicubu ezixhumene eziminyene ezingase zichazwe njenge-hyalinized noma i-fibrotic. Ngokuphambene nalokho okuvamile i-ovarian fibroma, lesi simila siqukethe inani elandisiwe izibalo ze-mitotic (amaseli wesimila ahlukana ukuze akhe amaseli amasha esimila) kanye nokuminyana okuphezulu sekukonke kwamaseli wesimila (inani lamaseli wesimila endaweni ethile yethishu). Izimila ezinkulu noma lezo esezinesikhathi eside zikhona zingase zibe nochungechunge lwezinguquko eziwohlokayo ezihlanganisa ukopha (ukopha ku-tumor) kanye nohlobo lwe-infarct. i-necrosis (ukufa kwamangqamuzana ngenxa yokuncipha kokugeleza kwegazi).

I-pathologist yakho ingase yenze ukuhlolwa okubizwa ngokuthi i-immunohistochemistry ukuze kuqinisekiswe ukuxilongwa. Lapho kwenziwa i-immunohistochemistry, amaseli wesimila ku-mitotically active cellular fibroma avame ukuba ne-inhibin, i-calretinin, i-WT1, nama-hormone receptors. i-estrogen receptor (ER) futhi i-progesterone receptor (PR).