T cells

Umbiko we-MyPathology
April 13, 2023

Ama-T cell (abizwa nangokuthi ama-T lymphocytes) awuhlobo lwengqamuzana elimhlophe legazi (WBC) kanye nengxenye yesimiso sokuzivikela komzimba. Iningi litholakala ezithweni ze-lymphoid ezifana ama-lymph node ezitholakala emzimbeni wonke. Izinombolo ezinkulu zalawa maseli zingatholakala futhi endaweni ye ukuvuvukala okubangelwa ukutheleleka noma ukulimala.

Ama-T cell avela kumaseli we-hematopoietic stem atholakala emnkantsheni. Lawa maseli abizwa ngokuthi ama-stem cell ngoba akhiqiza wonke amangqamuzana asegazini namasosha omzimba. Amangqamuzana abe esehamba aye esithweni okuthiwa i-thymus lapho ekhula khona ngaphambi kokungena egazini.

Uyini umsebenzi we-T cell?

Ama-T cell afaka isandla enqubweni ebizwa ngokuthi i-adaptive immune response. Ukusabela okuguquguqukayo kokuzivikela komzimba kubalulekile ekuvikeleni umzimba ezifweni. Lawa maseli asiza ezinye izinhlobo zamangqamuzana omzimba omzimba njengama-B cell ukuthi abone futhi alwe nezifo. Angaphinde abulale amangqamuzana angenwe yi-a igciwane.

Yiziphi izimpawu ezisetshenziselwa ukukhomba ama-T cell?

Omaka abajwayelekile abasetshenziselwa ukukhomba amaseli e-T ahlanganisa I-CD3 futhi I-CD5. Omaka abengeziwe njenge-CD4 ne-CD8 bangasetshenziswa ukukhomba izinhlobo ezincane zamaseli njengamaseli T asizayo namaseli e-cytotoxic T. Odokotela bezifo benza izivivinyo ezifana i-immunohistochemistry futhi ukugeleza kwe-cytometry ukubona amaseli enza i-CD3, CD5, CD4, kanye ne-CD8.

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