nguJason Wasserman MD PhD FRCPC
Mashi 22, 2023
I-oncocytic carcinoma ehlasela kakhulu uhlobo lomdlavuza wegilo. I-tumor ibizwa ngokuthi "i-invasive kabanzi" ngoba amaqembu amangqamuzana omdlavuza atholakala kuyo yonke indlala yegilo evamile. Elinye igama lalesi simila lithi I-Hurthle cell carcinoma ehlasela kakhulu.
Ukuxilongwa kwe-oncocytic carcinoma ehlasela kakhulu kungenziwa kuphela ngemva kokuba isimila sisusiwe futhi sithunyelwe kudokotela wezifo ukuze ahlolwe. Lokhu ngokuvamile kuhilela ukukhipha ngokuhlinzwa ingxenye yegilo yegilo nakuba ngezinye izikhathi yonke indlala yegilo ikhishwa. Ukuxilongwa akukwazi ukwenziwa ngemuva kwenqubo encane ehlaselayo ebizwa ngokuthi a i-fine needle aspiration biopsy (FNAB).
Uma ihlolwa ngesibonakhulu isimila sakhiwe ngombala obomvana omkhulu i-oncocytic amaseli. Amaseli avela pink ngoba icyoplasm (umzimba weseli) ugcwele ingxenye yeselula ebizwa ngokuthi i-mitochondria. Amaseli e-Oncocytic nawo anomjikelezo omkhulu nucleus (ingxenye yeseli ephethe izakhi zofuzo) kanye nendawo emaphakathi evelele i-nucleolus (inqwaba yezinto zofuzo phakathi nenucleus). Amaseli e-oncocytic angaxhuma ndawonye ukuze akhe izakhiwo eziyindilinga ezincane ezibizwa ngokuthi ama-follicles noma angase abe ngamaqembu amakhulu izazi zezifo eziwachaza ngokuthi 'iphethini eqinile'.
I-Oncocytic cell carcinoma ibizwa ngokuthi "i-invasive kabanzi" lapho amangqamuzana omdlavuza esabalele kuyo yonke indlala yegilo evamile. Ngokuphambene, amangqamuzana omdlavuza ohlotsheni oluhlobene lomdlavuza abizwa ngokuthi I-oncocytic carcinoma engavamile kakhulu ngokuvamile ahlukaniswa nendlala evamile yegilo ngongqimba oluncane lwezicubu okuthiwa a isimila capsule.
Ngemuva kokuthi isimila sikhishiwe sonke, sizokalwa futhi nosayizi wesimila uzofakwa embikweni wakho we-pathology. Usayizi wesimila ubalulekile ngoba usetshenziselwa ukunquma isigaba se-pathologic tumor (pT) futhi ngenxa yokuthi izimila ezinkulu kungenzeka zisabalele kwezinye izingxenye zomzimba.
I-Angioinvasion (i-vascular invasion) isho ukuthi amangqamuzana omdlavuza abonakale ngaphakathi komthambo wegazi okungenani owodwa. Kuvame kakhulu ukuthola i-angioinvasion ku-oncocytic carcinoma ehlasela kakhulu. I-Angioinvasion ibalulekile ngoba amangqamuzana omdlavuza angena emithanjeni yegazi akwazi ukusabalala kwezinye izingxenye zomzimba njengamaphaphu noma amathambo.
Ukuhlasela kwe-lymphatic kusho ukuthi amangqamuzana omdlavuza abonwa ngaphakathi komkhumbi we-lymphatic. Imikhumbi ye-lymphatic imigudu emincane emincane evumela udoti, uketshezi oluthe xaxa, namaseli ukuba kushiye izicubu. I-Lymphatics itholakala kuwo wonke umzimba. Ukuhlasela kwe-lymphatic kubalulekile ngoba kwandisa ingozi yokuthi amangqamuzana omdlavuza azotholakala endaweni i-lymph node. Ukuhlasela kwe-lymphatic akubonakali ngokuvamile ku-oncocytic carcinoma ehlaselayo.
Ukunwetshwa kwe-Extrathyroidal kusho ukuthi amangqamuzana omdlavuza asakazeke ngale kwegland yegilo kanye nasezicutshini ezizungezile. Amangqamuzana omdlavuza ahamba ngokwanele ngaphandle kwendlala yegilo angase ahlangane nezinye izitho ezinjengemisipha, umminzo, noma uqhoqhoqho.
Kunezinhlobo ezimbili ze-extrathyroidal extension:
I-Macroscopic (gross) extrathyroidal extension ibalulekile ngoba yandisa i-pathologic tumor stage (pT) futhi ihlotshaniswa nokubi kakhulu. isibikezelo. Ngokuphambene, isandiso se-microscopic extrathyroidal asishintshi isigaba sesimila futhi asihlotshaniswa nokubikezelwa okubi kakhulu.
A wekhasi yinoma yisiphi isicubu okufanele sisikwe udokotela ohlinzayo ukuze akhiphe indlala yegilo emzimbeni wakho. Imajini ibhekwa njengenhle lapho kunamaseli omdlavuza emaphethelweni ezicubu ezisikiwe. Umkhawulo ongemuhle usho ukuthi awekho amangqamuzana omdlavuza abonwe emaphethelweni asikiwe ezicubu.
Izindawo ezinama-lymph amasosha omzimba amancane atholakala kuwo wonke umzimba. Amangqamuzana omdlavuza angasakazeka esuka esimila kuye kuma-lymph nodes ngokusebenzisa imikhumbi emincane ebizwa ngokuthi i-lymphatics. Ngenxa yalesi sizathu, ama-lymph nodes avame ukususwa futhi ahlolwe ngesibonakhulu ukuze kubhekwe amangqamuzana omdlavuza. Ukuhamba kwamangqamuzana omdlavuza ukusuka esimila ukuya kwenye ingxenye yomzimba njenge-lymph node kubizwa ngokuthi a i-metastasis.
Ngezinye izikhathi ama-lymph nodes entanyeni akhishwa ngesikhathi esifanayo ne-thyroid ngendlela ebizwa ngokuthi i-neck dissection. Ama-lymph nodes asusiwe ngokuvamile avela ezindaweni ezahlukene zentamo futhi indawo ngayinye ibizwa ngokuthi izinga. Amazinga entanyeni anenombolo 1 kuya ku-7. Umbiko wakho we-pathology uzovame ukuchaza ukuthi mangaki ama-lymph node abonwe ezingeni ngalinye elithunyelwe ukuze lihlolwe. Ama-lymph nodes ohlangothini olufanayo nesimila abizwa ngokuthi i-ipsilateral kanti lawo aphesheya kwesimila abizwa ngokuthi i-contralateral.
Uma noma imaphi ama-lymph node akhishiwe emzimbeni wakho, azohlolwa ngesibonakhulu udokotela wezifo futhi imiphumela yalokhu kuhlolwa izochazwa embikweni wakho. Imibiko eminingi izobandakanya inani eliphelele lama-lymph nodes ahloliwe, lapho emzimbeni kutholwe khona ama-lymph nodes, kanye nenombolo (uma ikhona) equkethe amaseli omdlavuza. Uma amangqamuzana omdlavuza abonwa ku-lymph node, usayizi weqembu elikhulu kunawo wonke lamaseli omdlavuza (okuvame ukuchazwa ngokuthi “ukugxila” noma “idiphozithi”) nawo uzofakwa.
Ukuhlolwa kwama-lymph nodes kubalulekile ngenxa yezizathu ezimbili. Okokuqala, lolu lwazi lusetshenziselwa ukunquma isigaba se-pathologic nodal (pN). Okwesibili, ukuthola amangqamuzana omdlavuza ku-lymph node kwandisa ingozi yokuthi amangqamuzana omdlavuza azotholakala kwezinye izingxenye zomzimba esikhathini esizayo. Ngenxa yalokho, udokotela wakho uzosebenzisa lolu lwazi lapho enquma ukuthi kuyadingeka yini ukwelashwa okwengeziwe okufana ne-chemotherapy, i-radiation therapy, noma i-immunotherapy.
Kusho ukuthini uma i-lymph node ichazwa njenge-positive?
Izazi zezifo zivame ukusebenzisa igama elithi “positive” ukuchaza i-lymph node equkethe amangqamuzana omdlavuza. Isibonelo, i-lymph node equkethe amangqamuzana omdlavuza ingase ibizwe ngokuthi “positive for malignancy” noma “positive for metastatic carcinoma”.
Kusho ukuthini uma i-lymph node ichazwa njengenegethivu?
Izazi zezifo zivame ukusebenzisa igama elithi “negative” ukuchaza i-lymph node engenawo amangqamuzana omdlavuza. Isibonelo, i-lymph node enganawo amaseli omdlavuza ingase ibizwe ngokuthi “negative for malignancy” noma “negative for metastatic carcinoma”.
Isigaba se-pathologic se-invasive oncocytic carcinoma sisekelwe ohlelweni lwesiteji lwe-TNM, uhlelo olwaziwayo emhlabeni wonke olwasungulwa I-American Joint Committee on Cancer. Lolu hlelo lusebenzisa ulwazi mayelana nesimila esiyinhloko (T), ama-lymph node (N), futhi kude i-metastatic isifo (M) ukucacisa isigaba esiphelele se-pathologic (pTNM). I-pathologist yakho izohlola izicubu ezithunyelwe bese inika ingxenye ngayinye inombolo. Ngokuvamile, inani eliphakeme lisho isifo esithuthuke kakhulu futhi esibi kakhulu isibikezelo.
I-oncocytic carcinoma ehlasela kakhulu inikezwa isigaba sesimila phakathi kuka-1 no-4 ngokusekelwe kubukhulu besimila kanye nokuba khona kwamangqamuzana omdlavuza ngaphandle kwegilo.
I-oncocytic carcinoma ehlasela kakhulu inikezwa isigaba se-nodal sika-0 noma 1 ngokususelwa ebukhoneni noma ukungabikho kwamaseli omdlavuza endaweni. i-lymph node kanye nendawo yama-lymph nodes ahilelekile.
I-oncocytic carcinoma ehlasela kakhulu inikezwa isigaba se-metastatic sika-0 noma 1 ngokusekelwe ebukhoneni bamaseli wesimila endaweni ekude emzimbeni (ngokwesibonelo amaphaphu). Isigaba se-metastatic singanqunywa kuphela uma izicubu ezivela endaweni ekude zithunyelwa ukuze zihlolwe i-pathological. Ngenxa yokuthi lesi sicubu asivamile ukuthunyelwa, isigaba se-metastatic asikwazi ukunqunywa futhi sifakwe kuhlu njenge-MX.