Pathology dictionary



What does acanthosis mean?

Acanthosis is a word pathologists use to describe an increased number of specialized squamous cells in the skin. A similar change can also be seen on the inside of the mouth. It is a common non-cancerous change that can occur anywhere in the body where squamous cells are normally found.

The surface of the skin is called the epidermis. The epidermis is made up mostly of specialized cells called squamous cells. The normal thickness of the epidermis varies throughout the body.

Pathologists use the word acanthosis when the epidermis looks thicker than normal for that area of the body. It is a descriptive term for what is seen under the microscope and not a diagnosis although it is often used to help make a diagnosis.

Used alone, acanthosis is different than the diagnosis “acanthosis nigricans” which refers to a velvety thickening of the skin when examined without a microscope. Acanthosis nigricans does not show thickening of the epidermis when examined under the microscope.

What causes acanthosis?

The squamous cells give the skin its strength and acanthosis is often a response to ongoing and chronic irritation of the skin.

Common conditions associated with this change include:

  • Eczema
  • Psoriasis
  • Trauma caused by rubbing, itching, and scratching of the skin
  • Certain types of nevi
  • Dermatofibroma
  • Common warts
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