by Jason Wasserman MD PhD FRCPC
October 23, 2022

What is a cylindroma?

Cylindroma is a non-cancerous type of skin tumour. The tumour develops from sweat glands normally found in the skin. People with Brooke–Spiegler syndrome (BSS) commonly develop multiple cylindromas. This syndrome is associated with an alteration in the gene CLYD.

Where are cylindromas found?

Cylindromas are typically found on the head and neck but the upper chest and back can also be involved.

What causes a cylindroma?

For most patients, the cause of a cylindroma remains unknown. However, patients with the genetic syndrome Brooke–Spiegler syndrome (BSS) are known to develop multiple cylindromas. In patients with BSS, the tumours are caused by a change in the gene CYLD.

Can a cylindroma turn into cancer over time?

No. A cylindroma is a non-cancerous tumour that will not turn into cancer over time.

How do pathologists make the diagnosis of cylindroma?

The diagnosis is usually made after the entire tumour has been removed in a procedure called an excision. The diagnosis can also be made after only a small part of the tumour is removed in a procedure called a biopsy.

What is a margin?

A margin is any tissue that was cut by the surgeon in order to remove the tumour from your body. A negative margin means there were no tumour cells at the edge of the tissue. A margin is considered positive when there are tumour cells at the edge of the tissue. A positive margin is associated with a higher risk that the tumour will grow back (recur) in the same site after treatment.


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