by Jason Wasserman MD PhD FRCPC
April 24, 2023

What is a squamous papilloma?

Squamous papilloma is a non-cancerous growth made up of specialized squamous cells that connect together to form finger-like projections called papilla. This type of growth can start in any location where squamous cells are normally found such as the skin, mouth, tonsils, larynx, esophagus, and eyelids.

What causes a squamous papilloma?

Most squamous papillomas are caused by human papillomavirus (HPV). The growth develops after the normal squamous cells become infected with the virus and start to grow. Some squamous papillomas are caused by trauma while those in the esophagus can be caused by prolonged acid reflux disease (GERD) and may be seen in people with reflux esophagitis.

Can a squamous papilloma turn into cancer?

No. Squamous papillomas are non-cancerous growths that will not change into cancer over time. However, growths caused by human papillomavirus (HPV) can re-grow over time or new growths may develop if other squamous cells in the same area are also infected with the virus.