by Jason Wasserman MD PhD FRCPC
April 19, 2022
About this article: This article was created by doctors to help you read and understand your pathology report for squamous papilloma. If you have any questions about this article or your pathology report, please contact us.
Squamous papilloma is a non-cancerous growth made up of specialized squamous cells that connect together to form finger-like projections called papilla. This type of growth can start in any location where squamous cells are normally found such as the skin, mouth, tonsils, larynx, esophagus, and eyelids.
Most squamous papillomas are caused by human papillomavirus (HPV). The growth develops after the normal squamous cells become infected with the virus and start to grow. Some squamous papillomas are caused by trauma while those in the esophagus can be caused by prolonged acid reflux disease (GERD) and may be seen in people with reflux esophagitis.
No. Squamous papillomas are non-cancerous growths that will not change into cancer over time. However, growths caused by human papillomavirus (HPV) can re-grow over time or new growths may develop if other squamous cells in the same area are also infected with the virus.