July 25, 2023
In pathology, the term degenerative changes describes the microscopic appearance of tissue that has undergone physical breakdown so that it no longer resembles normal healthy tissue. Degenerative changes can prevent a tissue or organ from functioning normally.
No. Degenerative change does not mean cancer. However, some tumours (including cancers) can show degenerative changes especially if the tumour is large or if the tumour was previously treated.
Causes of degenerative changes include ageing, toxins, chronic disease (such as diabetes, hypertension, or osteoarthritis), trauma, and ischemia (loss of blood supply to the tissue). Some types of tumours can show degenerative changes as a result of a prior medical procedure such as a biopsy or after treatment with chemotherapy or radiation therapy. Large or fast-growing tumours can also show degenerative changes due to insufficient or decreased blood flow.
Pathologists use the term “extensive” to mean that the changes were seen throughout the tissue being examined.