Direct immunofluorescence

by Jason Wasserman MD PhD FRCPC
June 1, 2022

What is direct immunofluorescence?

Direct immunofluorescence (DIF) is a test that pathologists perform to look for specific proteins in a tissue sample. Unlike most tissue samples, which are examined using normal light, DIF tissue samples are examined using fluorescent light. This makes it easier for your pathologist to see any abnormal proteins in the sample. DIF is commonly used to look for abnormal proteins in skin and kidney biopsies.

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