Lymphohistiocytic

Lymphohistiocytic is a term pathologists use to describe a type of inflammation involving two kinds of immune cells: lymphocytes and histiocytes. Lymphocytes are white blood cells that help your body fight infections, while histiocytes are cells that remove harmful substances and help repair damaged tissues. Together, these cells indicate that your immune system is responding to some form of injury or irritation.

What causes lymphohistiocytic inflammation?

Lymphohistiocytic inflammation can occur for several reasons, including infections, autoimmune diseases (conditions where the immune system mistakenly attacks your own tissues), allergic reactions, or as a reaction to chronic irritation or injury. In some cases, the exact cause may not be clearly identifiable.

What does it mean if lymphohistiocytic cells are described as an infiltrate or an aggregate?

If your pathology report mentions a lymphohistiocytic infiltrate, it means these immune cells are scattered throughout the affected tissue. This scattered pattern usually indicates a reaction to something irritating or damaging the tissue. If the report describes a lymphohistiocytic aggregate, it means these cells are grouped closely together, forming a cluster. Clusters often suggest a more targeted or organized immune response and can sometimes be seen in chronic conditions, infections, or certain autoimmune disorders. Your doctor will use this information, along with your clinical history and symptoms, to determine the best next steps in your care.