Neuroblasts

Neuroblasts are immature nerve cells. During early development, especially before birth and in the first few years of life, neuroblasts gradually mature to become fully functioning nerve cells called neurons. These neurons are essential for transmitting messages throughout the body and supporting normal brain function.

Where are neuroblasts normally found?

Neuroblasts are normally found in developing babies and young children. They form in areas known as neural crest tissue and are mainly located near the adrenal glands (which sit above the kidneys), as well as along the spine and within nerve tissues throughout the body. After early childhood, most neuroblasts mature into neurons, and very few neuroblasts remain.

What types of tumours start from neuroblasts?

Tumours that start from neuroblasts are called neuroblastic tumours. The most common of these is neuroblastoma, which typically affects young children. Other related tumours include ganglioneuroblastoma and ganglioneuroma. These tumours vary in how much they resemble normal nerve cells under the microscope and in how they behave (how aggressive or slow-growing they are).

What do neuroblasts look like under the microscope?

Under the microscope, neuroblasts appear as small, round cells with very little cytoplasm (the space around the nucleus of the cell). The nucleus (the center of the cell) is dark and may have a finely speckled appearance, often described as “salt-and-pepper.” Neuroblasts frequently cluster together in groups or form circular patterns known as rosettes, particularly Homer Wright rosettes, which are characteristic features seen in some neuroblastic tumors.