November 14, 2023

p63 is a protein made by normal cells in the skin, salivary glands, breast, prostate gland, and bladder. Tumours that arise from these cells also produce p63. After it is made, p63 is held in a part of the cell called the nucleus.

Immunohistochemistry (IHC) is a test pathologists perform to see p63-producing cells in a tissue sample. When combined with other immunohistochemical markers, this test allows pathologists to determine if the cells they are seeing under the microscope come from one of the organ systems that normally produces this protein. Pathologists use the results of this test combined with other features to make a diagnosis.

About this article

This article was written by doctors to help you read and understand your pathology report. Contact us if you have questions about this article or your pathology report. For a complete introduction to your pathology report, read this article.

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Atlas of pathology
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