The term suspicious for malignancy is used in pathology reports to describe a finding that has features of cancer but lacks enough definitive evidence to confirm the diagnosis. This term indicates that while cancer is strongly suspected, further evaluation or testing is needed to make a final determination.
When do pathologists use the term suspicious for malignancy?
Pathologists use the term suspicious for malignancy when the tissue sample shows some, but not all, of the characteristics typically seen in cancer. This can happen when the sample is very small, such as in a biopsy, or when the cells are altered, making them difficult to classify. In these cases, the pathologist wants to convey a strong concern for cancer while acknowledging the uncertainty of the findings.
Can something described as suspicious for malignancy be benign?
Yes, in some cases, something described as suspicious for malignancy can turn out to be benign (non-cancerous). Certain non-cancerous conditions can mimic cancer under the microscope, making it difficult to differentiate between them based on limited information. However, this term emphasizes the need for further evaluation to rule out or confirm cancer.
What additional tests may be performed and why?
If a finding is described as suspicious for malignancy, additional tests may be performed to clarify the diagnosis. These tests can include:
- Immunohistochemistry: This test uses special stains to identify proteins in the cells, helping to determine their origin and behavior.
- Molecular tests: Tests like fluorescence in situ hybridization (FISH) or next-generation sequencing (NGS) can look for genetic changes commonly associated with cancer.
- Additional biopsy or surgery: Obtaining more tissue can provide a larger sample for examination, allowing the pathologist to see more of the tumour and make a more definitive diagnosis.
These tests are critical for distinguishing between benign and malignant conditions and for identifying the type of cancer if it is present.
What should happen next?
If your pathology report includes the term suspicious for malignancy, your doctor will discuss the next steps with you. This may involve additional tests, a repeat biopsy, or surgery to remove more tissue for examination. The goal is to gather enough information to confirm or rule out a diagnosis of cancer and to determine the most appropriate treatment plan if cancer is confirmed.
It’s important to ask your doctor any questions you have about your diagnosis and the next steps in your care. Understanding the meaning of suspicious for malignancy can help you feel more informed and involved in the decision-making process.
We are proud to partner with:
Our work is generously supported by:
