October 17, 2023
Tumour infiltrating lymphocytes (TILs) are immune cells (typically T cells) that gather around or inside a tumour. TILs are important because they can kill cancer cells and prevent the disease from spreading to other parts of the body. Immune checkpoint inhibitors (such as PD-L1 inhibitors) work by preventing cancer cells from blocking the natural activity of TILs.
When examining a tumour for TILs, pathologists typically use two categories to describe the response:
Tumours with non-brisk TILs are more likely to spread to a lymph node or a distant part of the body such as the lungs.
This article was written by doctors to help you read and understand your pathology report. Contact us if you have questions about this article or your pathology report.