ALK

ALK Rearrangements in Lung Cancer

ALK (anaplastic lymphoma kinase) is a protein that plays a role in normal cell development. In healthy adult lung tissue, the ALK gene is essentially switched off. In approximately 3–7% of non-small cell lung cancers, a chromosomal rearrangement — a structural change in which a segment of DNA breaks and fuses to a different gene …
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ALK: Definition

ALK (anaplastic lymphoma kinase) is a gene that normally plays a role in the development of nerve cells. In healthy adult tissue, the ALK gene is essentially switched off, producing little to no protein. In some cancers, however, a structural change in the DNA causes the ALK gene to fuse with another gene — a …
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