Unicentric Castleman disease (UCD) is a rare, non-cancerous condition that affects lymph nodes. Lymph nodes are small structures found throughout the body that help fight infection. In UCD, only a single lymph node or a group of lymph nodes in a specific area is involved. UCD typically has benign features, meaning it is not cancerous …
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Castleman disease is a rare condition that affects the lymph nodes and the immune system. It involves abnormal growth and inflammation of lymph nodes, leading to various health issues depending on the subtype and extent of involvement. There are different types of Castleman disease, each with distinct characteristics, causes, and clinical outcomes. What are the …
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Idiopathic multicentric Castleman disease (often called iMCD) is a rare disorder that involves an overactive immune system, leading to inflammation throughout the body. The disease affects multiple lymph nodes, causing them to enlarge and produce excessive amounts of inflammatory chemicals called cytokines. This results in symptoms such as fever, fatigue, and problems in several organs. …
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HHV8-associated multicentric Castleman disease (also called KSHV/HHV8-associated multicentric Castleman disease) is a condition in which the immune system creates a large number of abnormal cells called plasmablasts, due to infection by a virus known as human herpesvirus-8 (HHV8). This leads to enlarged lymph nodes, inflammation throughout the body, and systemic symptoms, such as fever and …
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