chronic myeloid leukemia

BCR::ABL1 (Philadelphia Chromosome) in Chronic Myeloid Leukemia

If your blood test or bone marrow report mentions BCR::ABL1 or the Philadelphia chromosome, these refer to the same genetic change — a mistake in the DNA of a blood-forming cell that causes it to produce a new, abnormal protein. That protein drives the uncontrolled growth of white blood cells seen in chronic myeloid leukemia …
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Chronic Myeloid Leukemia (CML): Understanding Your Pathology Report

Chronic myeloid leukaemia is a type of blood cancer called a myeloproliferative neoplasm. It is defined by an abnormal fusion gene called BCR::ABL1. This gene causes the bone marrow to produce too many white blood cells, especially myelocytes and neutrophils, which normally help fight infection. Most people are diagnosed at an early, slow-growing stage called …
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