If your test results mention a 17p deletion or a TP53 mutation, these findings both relate to the same gene — TP53 —, and together they represent the most clinically significant molecular finding in chronic lymphocytic leukemia (CLL). A 17p deletion removes one physical copy of the TP53 gene from the leukemia cell; a TP53 …
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If your test results include a finding about IGHV mutation status — reported as either mutated or unmutated — this refers to the result of a test that looks at a specific part of the DNA of your chronic lymphocytic leukemia (CLL) cells. IGHV mutation status is one of the strongest prognostic markers in CLL …
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If your blood, bone marrow, or molecular test report mentions a TP53 mutation or a 17p deletion, both findings relate to the same gene. TP53 produces one of the body’s most important proteins for preventing cancer, and when it stops working, cancer cells become harder to kill with treatments that rely on it. These changes …
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Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults. It is a slow-growing (indolent) blood cancer that starts in B cells — the white blood cells that help the body fight infections by producing antibodies. In CLL, a single abnormal B cell multiplies uncontrollably, producing a large population of abnormal identical …
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