If your pathology or molecular report mentions p53, it refers to the result of a special stain or genetic test that looks at a protein — and the gene that makes it — that plays a central role in how cells control their own growth and repair their DNA. In endometrial cancer, testing for p53 …
Read More »
A POLE mutation is one of the most important findings a pathologist can report in an endometrial cancer — not because it signals danger, but because it signals the opposite. Endometrial cancers with a pathogenic POLE mutation belong to the molecular group with the best prognosis of all four endometrial cancer subtypes. These cancers rarely …
Read More »
Dedifferentiated carcinoma of the endometrium is an aggressive type of cancer that starts in the endometrium, the inner lining of the uterus. It is called “dedifferentiated” because the tumour comprises two components: an undifferentiated carcinoma component and a second differentiated component. The differentiated component is most often a low-grade form of endometrial endometrioid carcinoma (FIGO …
Read More »
Undifferentiated carcinoma of the endometrium is an aggressive type of cancer that starts in the endometrium, the inner lining of the uterus. It is called “undifferentiated” because the tumour cells do not show clear features indicating which type of normal cell they came from. In other words, when the tumour is examined under the microscope, …
Read More »
High-grade endometrial stromal sarcoma is an aggressive type of cancer that originates from the supportive stromal tissue within the uterus. The term “high-grade” indicates that these cancer cells grow rapidly, appear very abnormal under a microscope, and are more likely to spread beyond the uterus compared to low-grade types. What causes high-grade endometrial stromal sarcoma? …
Read More »
Endometrial clear cell carcinoma is a rare type of cancer that starts in the endometrium, the inner lining of the uterus. It is considered a high-grade tumour, meaning it has a higher chance of spreading beyond the uterus compared to low-grade endometrial cancers. Endometrial clear cell carcinoma behaves differently from the more common endometrial endometrioid …
Read More »
Endometrial serous carcinoma is an aggressive type of cancer that starts in the endometrium, the inner lining of the uterus. It is considered a high-grade tumour, meaning it has a higher chance of spreading beyond the uterus compared to some other types of endometrial cancer. Unlike endometrial endometrioid carcinoma, which is often linked to excess …
Read More »
Endometrial endometrioid carcinoma is a type of cancer that begins in the endometrium, the inner lining of the uterus. It is the most common type of endometrial cancer and most often affects women after menopause. This type of cancer frequently develops from a precancerous condition called atypical endometrial hyperplasia, in which the endometrial cells show …
Read More »
