molecular pathology

Tumor suppressor gene

A tumor suppressor gene is a type of gene that helps protect the body from cancer. These genes normally control how cells grow, divide, and repair themselves. When working correctly, tumor suppressor genes act like brakes that slow down cell division, fix DNA damage, or cause unhealthy cells to die before they can become cancer. …
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Translocation

A translocation is a specific type of genetic change where a piece of one chromosome breaks off and attaches to another chromosome. Chromosomes are structures inside your cells that carry DNA, which contains the instructions your body needs to grow and function. When pieces of chromosomes switch places, they create new combinations of genetic material. …
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Fusion

In a molecular pathology report, the word fusion refers to a specific genetic change in which two different genes that are normally separate join together. This joining creates a new, hybrid gene that produces an abnormal protein. These fusion events happen inside the cancer cells and are not something a person is born with. Because …
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