Li-Fraumeni syndrome is an inherited condition that raises the lifetime risk of a wide range of cancers, often beginning in childhood or early adulthood. It is caused by a change in a single gene, TP53. Some centers now use the broader term heritable TP53-related cancer syndrome, because carriers are increasingly identified who do not fit …
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If your blood, bone marrow, or molecular test report mentions a TP53 mutation or a 17p deletion, these findings both relate to the same gene — TP53 — which produces one of the most important proteins in the body’s system for preventing cancer. In blood cancers, losing the function of this gene is associated with …
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If your pathology or molecular report mentions p53, it refers to the result of a special stain or genetic test that looks at a protein — and the gene that makes it — that plays a central role in how cells control their own growth and repair their DNA. In endometrial cancer, testing for p53 …
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p53 is a protein made by a gene called TP53, which plays a critical role in protecting the body from cancer. Because of this, p53 is known as a tumor suppressor. The TP53 gene is located on chromosome 17 and provides instructions for making the p53 protein, which works like a quality control inspector inside …
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