by Adnan Karavelic, MD FRCPC
November 28, 2022
Disordered proliferative endometrium is a non-cancerous change that develops in the endometrium, a thin layer of tissue that lines the inside of the uterus. If left untreated, disordered proliferative endometrium can change into another non-cancerous condition called endometrial hyperplasia.
The changes seen in disordered proliferative endometrium are believed to be caused by long-standing and unopposed stimulation of the endometrium by the hormone estrogen. Unopposed means that the effects of estrogen are not being balanced by other hormones such as progesterone. Unopposed estrogen stimulation is common in perimenopausal women, younger women with excess body fat, and in women with polycystic ovarian syndrome (PCOS).
No. The evidence available today suggests that this condition does is not associated with an increased risk of developing endometrial cancer.
This diagnosis is made after a small tissue sample from the endometrium is examined under the microscope by a pathologist.
Disordered proliferative endometrium is a descriptive diagnosis that needs to be considered together with your medical history, physical examination, and any other tests that were performed (blood work, imaging tests, etc.). Talk to your doctor about what this diagnosis means to you.