A supratentorial ependymoma is a brain tumour composed of ependymal cells, which normally line the fluid-filled spaces (ventricles) of the brain and the central canal of the spinal cord. “Supratentorial” means the tumour is above the tentorium, the membrane that separates the upper brain (cerebrum) from the lower back part of the brain (cerebellum and brainstem). …
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In a molecular pathology report, the word rearrangement refers to a change in the DNA structure within a cell. DNA is usually organized into long strands called chromosomes, each containing many genes. A rearrangement happens when a piece of a chromosome breaks off and attaches somewhere else, either on the same chromosome or another chromosome. …
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In a molecular pathology report, the word fusion refers to a specific genetic change in which two different genes that are normally separate join together. This joining creates a new, hybrid gene that produces an abnormal protein. These fusion events happen inside the cancer cells and are not something a person is born with. Because …
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What is next-generation sequencing? Next-generation sequencing (NGS) is a way of finding out the order of the letters in DNA or RNA, the genetic material inside our cells. DNA and RNA are made of four different letters: A, C, G, and T for DNA, and A, C, G, and U for RNA. The order of …
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