If your blood or bone marrow report mentions a JAK2 mutation — most often written as JAK2 V617F — this refers to a change in a gene that controls how blood cells are made in the bone marrow. JAK2 mutations are the most common molecular finding across the group of blood conditions called myeloproliferative neoplasms …
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Polycythemia vera is a type of blood cancer called a myeloproliferative neoplasm. It is characterized by the bone marrow producing too many red blood cells. Many people also have increased white blood cells and or platelets. In most cases, polycythemia vera is caused by an acquired genetic change in a gene called JAK2 that sends …
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JAK2 (Janus kinase 2) is a gene that provides instructions for making a protein involved in how cells grow, divide, and respond to signals from the immune system. JAK2 is part of a family of related genes that also includes JAK1, JAK3, and TYK2. These genes all produce proteins that help cells communicate using a …
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