NKX3.1 is a specialized protein known as a transcription factor, meaning it helps regulate how certain genes are turned on or off within cells. It plays a crucial role in the normal development and functioning of the prostate gland, particularly in forming the prostate’s ducts and the epithelium (lining cells). The production of NKX3.1 in …
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Atypical small acinar proliferation (ASAP) is a term pathologists use when examining a prostate biopsy under a microscope. It describes a small group of atypical prostate glands that could represent reactive features, benign (noncancerous) entities, or low grade prostate cancer. The microscopic features of ASAP are insufficient to establish a definitive cancer diagnosis, although it …
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Background: Intraductal carcinoma of the prostate gland is a noninvasive tumour characterized by the proliferation of malignant cells within the ducts and acini of the prostate gland. Unlike invasive prostate cancer, the tumour cells in intraductal carcinoma are found within the ductal system and do not invade the surrounding prostate tissue. However, this condition is …
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A postoperative spindle cell nodule is a non-cancerous growth that can develop after certain surgical procedures or manipulations. Although it may sometimes be mistaken for cancer under a microscope, this condition is entirely benign (non-cancerous). Other names for this condition include pseudosarcomatous myofibroblastic proliferation and pseudosarcomatous myofibroblastic neoplasm. Where are postoperative spindle cell nodules typically …
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High grade prostatic intraepithelial neoplasia (HGPIN) is a condition in which the cells that line the ducts and glands of the prostate gland show abnormal changes. These changes are not cancerous, but they are considered precancerous, meaning they may develop into prostate cancer over time. HGPIN is often detected in prostate biopsies, which are usually …
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Prostatic adenocarcinoma is the most common type of prostate cancer. This type of cancer may also be described as acinar adenocarcinoma because it is made up of groups of tumour cells forming small glands called acini. It develops from epithelial cells normally found in the prostate gland. Adenocarcinoma of the prostate is a relatively common …
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Background: Benign prostatic hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland and one of the most common conditions that affect men as they get older. What are the symptoms of benign prostatic hyperplasia? The symptoms of BPH develop because the prostate increases in size, and this growth compresses the urethra. This compression makes …
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