Succinate dehydrogenase-deficient renal cell carcinoma (often called SDH-deficient RCC) is a rare type of kidney cancer. It occurs when a gene called succinate dehydrogenase (SDH) doesn’t function properly due to mutations. SDH is important for normal cell function and energy production. When this gene isn’t working, it can cause cells in the kidney to grow …
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Fumarate hydratase-deficient renal cell carcinoma (often called FH-deficient RCC) is a rare type of kidney cancer. It develops due to mutations (changes) in a gene called fumarate hydratase (FH). FH is important for normal cell metabolism. Changes in this gene lead to the formation of a tumour with specific microscopic features. This tumour often behaves …
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Tubulocystic renal cell carcinoma (TcRCC) is a rare type of kidney cancer. It begins in very small tubes (tubules) and cysts within the kidney. A cyst is a small sac filled with fluid. These tumours typically have a cystic appearance, meaning they contain multiple small cysts. Tubulocystic renal cell carcinoma is usually a slow-growing tumour …
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What is Xp11 translocation renal cell carcinoma? Xp11 translocation renal cell carcinoma (RCC) is a type of kidney cancer. It is called ‘Xp11 translocation’ because the tumour cells contain a genetic alteration involving the TFE3 gene which is located in the p11 region of chromosome X. Another name for this type of cancer is TFE3-rearranged …
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What is TFE3-rearranged renal cell carcinoma? TFE3-rearranged renal cell carcinoma (RCC) is a type of kidney cancer. It is called ‘TFE3-rearranged’ because the tumour cells contain a genetic alteration involving the TFE3 gene. Another name for this type of cancer is Xp11 translocation renal cell carcinoma. What causes TFE3-rearranged renal cell carcinoma? This type of …
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The Fuhrman grade is a system used to classify the aggressiveness of renal cell carcinoma (RCC), which is the most common type of kidney cancer. Developed by Gary A. Fuhrman in the 1980s, this grading system helps pathologists and oncologists evaluate how cancer cells look under a microscope compared to normal kidney cells. The Fuhrman …
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