by Adnan Karavelic, MD FRCPC
May 27, 2022
Atrophic endometrium is a term used to describe a non-cancerous change in the endometrium, the tissue that covers the inside of the uterus. This change results from a process called atrophy. When a tissue undergoes atrophy, it becomes smaller and no longer functions normally.
The diagnosis is usually made after a sample of endometrial tissue is removed in a procedure called a biopsy or a curettage. The tissue is then sent to a pathologist who examines it under the microscope.
Atrophic endometrium is different from the normal endometrium in the following ways:
Atrophic endometrium is a normal finding in prepubertal, postmenopausal, and some perimenopausal women. However, it can also be seen with pre-cancerous or cancerous diseases and your doctor may suggest a biopsy of the endometrium to look for more serious conditions.
Some, but not all features of atrophy may also be seen in women of fertile age (between the early teens and the age of 45-55 years) who are still menstruating, but use some method of contraception, such as oral contraceptive pills or have an intrauterine contraceptive device (IUD) inserted. Common IUD products are Liletta, Kyleena, Mirena, and Skyla.
The use of any method of contraception is important information for both clinicians and pathologists. It should be recorded in the clinical notes and on the pathology requisition form.
In pathology reports, atrophic endometrium is sometimes called non-proliferative or inactive endometrium (with atrophic changes).