High grade squamous intraepithelial lesion of the anus and anal canal
High grade squamous intraepithelial lesion (HSIL) is a precancerous disease caused by human papillomavirus (HPV). It is composed of abnormal squamous cells that have been infected and transformed by the virus. Squamous cells are found in a thin layer of tissue called the epithelium which covers the inside surface of the anus and anal canal. …
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