Antral type mucosa refers to the specialized tissue that lines the antrum, which is the lower part of the stomach just before it connects to the small intestine. Pathologists use this term in pathology reports to describe the normal lining found in this region. Because the stomach has different regions that perform slightly different functions, …
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Fibrinopurulent exudate is a type of fluid that accumulates at a site of tissue damage or inflammation, which contains a combination of fibrin, inflammatory cells such as neutrophils, and cellular debris. Fibrin is a protein that plays a role in blood clotting, and it can form a mesh-like network that helps to hold the exudate …
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Squamous epithelium is a thin layer of tissue made up of flat cells called squamous cells. These cells form a protective barrier on the surface of various organs and tissues throughout the body, helping to protect the underlying tissues from injury, infection, and irritation. Where is squamous epithelium found in the body? Squamous epithelium is …
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Squamous mucosa is a thin, protective lining made up of specialized cells called squamous cells. This lining covers the inner surfaces of several areas of your body, including your mouth, esophagus, vagina, cervix, and anal canal. It also lines parts of your respiratory system, such as your nasal cavity, throat (pharynx), voice box (larynx), windpipe …
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Natural killer cells, often called NK cells, are a type of lymphocyte, which is a white blood cell that plays an important role in the body’s immune system. They are part of the innate immune system, meaning they can respond quickly to threats without needing prior exposure to the specific invader. NK cells are called …
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CD45 is a protein found on the surface of most cells in the immune system, including white blood cells (also called leukocytes). CD45 helps these immune cells communicate and respond appropriately to infections and inflammation. Why do pathologists test for CD45? Pathologists test for CD45 to help determine if cells seen in a tissue sample …
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AE1/AE3 is a laboratory test used by pathologists to help identify the origin of a tumour. It works by detecting proteins called cytokeratins — structural proteins found inside epithelial cells, which line the surfaces of organs and glands throughout the body. AE1/AE3 is not a single protein — it is a combination of two antibodies, …
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In pathology, the phrase degenerative changes describes tissue that has started to physically break down, losing its normal structure and appearance when viewed under a microscope. These changes can affect how well a tissue or organ functions. Although degenerative changes themselves are not cancerous, they may sometimes be seen in tumours, particularly if the tumour …
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HBME-1, which stands for “Hector Battifora mesothelial-1,” is an antibody that binds to a specific protein called mesothelin. It is primarily used in pathology to help identify specific types of cells, particularly in the diagnosis of certain tumours. The marker is most commonly associated with mesothelial cells (which line the body’s cavities) and some types …
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HMB-45 (Human Melanoma Black-45) is an antibody used by pathologists to detect a protein called gp100. This protein is normally found in melanocytes—cells that produce melanin, the pigment responsible for skin, hair, and eye color. Melanocytes are mostly located in the skin but can also appear in mucosal areas (like the mouth) and eyes. Because …
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