The Pathology Dictionary Team
February 17, 2023
HBME-1 (Hector Battifora Mesothelial-1) is an antibody that binds to a protein called mesothelin. This protein is normally expressed in mesothelial cells that line the body cavities but is also expressed in a type of thyroid gland cancer called papillary thyroid carcinoma (PTC).
HBME-1 staining is used by pathologists to aid in the diagnosis of a type of thyroid cancer called papillary thyroid carcinoma (PTC). In this context is it used to help distinguish papillary thyroid carcinoma from other types of thyroid tumours and non-tumoural thyroid conditions.
Pathologists perform a test called immunohistochemistry to look for cells that express HBME-1. The test is typically performed after the entire tumour has been removed along with part or all of the thyroid gland.
Positive for HBME-1 means that the cells in the tissue sample express mesothelin.
Negative for HBME-1 means that the cells in the tissue sample do not express mesothelin.