Diffuse large B cell lymphoma (DLBCL) with MYC and BCL2 rearrangements is a type of cancer affecting B cells, a white blood cell that helps protect the body from infections. In this condition, the cancer cells grow and spread quickly. The term “diffuse” refers to how the cancer cells spread out and replace normal tissue. In this …
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A hyperplastic tonsil is a benign (non-cancerous) condition that results from an increased number of cells normally found in the tonsil. The tonsils are small masses of lymphoid tissue located at the back of your throat and play a role in your immune system by helping to trap and fight off infections. When the number …
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CD117, also known as c-kit, is a protein that acts as a receptor on the surface of specific cells in the body. It is involved in cell growth, survival, and development, particularly in cells that form part of the blood, skin, and digestive system. This protein plays a critical role in normal cell function, especially …
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ERG is a protein found in the cells of certain tissues in the body. It is a transcription factor, which means it helps control how specific genes are turned on or off inside the cell. ERG is involved in the normal development of blood vessels and plays a role in the growth of certain types …
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Non-keratinizing squamous cell carcinoma (also known as non-keratinizing nasopharyngeal carcinoma) is the most common type of nasopharyngeal cancer. It starts in the nasopharynx, the upper part of the throat located behind the nose. The tumour arises from the squamous cells that line the surface of the nasopharynx. What are the symptoms of non-keratinizing squamous cell …
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Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare type of lymphoma that affects a part of the immune system called the lymph nodes. It is a slow-growing cancer that starts in B cells, a type of white blood cell that helps the body fight infections. The World Health Organization recommends the term “nodular lymphocyte …
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Reed-Sternberg cells are a specific type of abnormal cell found in certain cancers. These cells are large, with a distinctive appearance under the microscope, and they play an important role in the diagnosis of a cancer called Hodgkin lymphoma. Reed-Sternberg cells are believed to be derived from a white blood cell type known as a …
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Classic Hodgkin lymphoma (CHL) is a type of cancer that starts in the lymph nodes, which are part of the body’s immune system. It involves a specific type of cell called the Reed-Sternberg cell, which is abnormal and larger than normal lymphocytes (a type of white blood cell). This type of cancer is known for …
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Nodular lymphocyte predominant B cell lymphoma (NLPBCL) is a rare type of lymphoma that affects a part of the immune system called the lymph nodes. It is a slow-growing cancer that starts in B cells, a type of white blood cell that helps the body fight infections. The International Consensus Classification recommends the term “nodular …
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The Hans algorithm is a tool used by pathologists to classify diffuse large B cell lymphoma (DLBCL) into different subtypes based on the expression of specific proteins in the cancer cells. DLBCL is the most common type of non-Hodgkin lymphoma, and it can be divided into two main subtypes: germinal center B-cell-like (GCB) and activated …
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