HSIL

What is high grade squamous intraepithelial lesion (HSIL)?

High grade squamous intraepithelial lesion (HSIL) is a precancerous condition caused by infection with human papillomavirus (HPV). It involves abnormal changes in squamous cells, which are flat cells found on the surface of tissues such as the cervix, vagina, vulva, penis, and anal canal. HSIL is primarily caused by high-risk HPV types, especially types 16 …
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p16: Definiton

p16 is a protein produced by cells throughout the body that helps control how cells grow and divide. Because it acts as a brake on cell growth, p16 is known as a tumor suppressor protein — a protein whose normal job is to prevent cells from growing uncontrollably. In pathology, p16 is most commonly used …
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