Hematopoiesis is the process by which the body produces new blood cells. The word comes from the Greek words “hema,” meaning blood, and “poiesis,” meaning formation. Hematopoiesis is essential for maintaining the body’s supply of red blood cells (RBCs), white blood cells (WBCs), and platelets, which are all crucial for carrying oxygen, fighting infections, and …
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Definition: Comedonecrosis is a pattern of cell death seen in certain types of tumours. The word “comedo” comes from a term used to describe a blocked pore, and “necrosis” means dead tissue. In the context of cancer, comedonecrosis describes dead cancer cells found in clusters within a tumour. These cells often die because they are …
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Dedifferentiation (or dedifferentiated) in pathology refers to the process where mature, specialized cells revert to a more primitive, less specialized state. This phenomenon is typically observed in cancer cells, where the tumor progresses from a differentiated, often less aggressive state to a less differentiated, more aggressive state. Dedifferentiated cells exhibit higher levels of proliferative activity …
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Amyloid is a type of abnormal protein that can accumulate in tissues and organs. Unlike normal proteins, amyloid proteins fold into an unusual shape, forming clumps or fibrils that can interfere with the normal function of tissues and organs. What is the significance of finding amyloid in a tissue sample? The presence of amyloid in …
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A “fibromyxoid tumour” is not a specific diagnosis but a descriptive term that refers to various benign (noncancerous) or malignant (cancerous) tumours characterized by the presence of fibrous and myxoid tissue components. These tumours can arise in both soft tissues and bone throughout the body, and their behaviour depends on whether they are ultimately determined …
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Lymphoblasts are immature cells that develop into lymphocytes, a type of white blood cell that is integral to the immune system. They are part of the body’s adaptive immune response, responsible for fighting infections and providing long-term immunity. Where are lymphoblasts normally found? Lymphoblasts are primarily found in the bone marrow, the soft, spongy center …
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ECL cell hyperplasia refers to an increase in the number of enterochromaffin-like (ECL) cells within the stomach lining. ECL cells are neuroendocrine cells that play an important role in the regulation of acid production in the stomach. Where are ECL (enterochromaffin-like) cells normally found, and what do they do? ECL cells are normally found in …
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Intranuclear inclusions are abnormal collections of protein or other material found within the nucleus of a cell. These inclusions appear as rounded, compact masses that are often distinct from the surrounding nuclear material because of their colour, density, or composition. Medical conditions associated with intranuclear inclusions Intranuclear inclusions are associated with various medical conditions, the …
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Goblet cells are large, round, mucin-filled cells found in the body’s mucous membranes. They are responsible for producing mucus. This secretion is a protective lubricant coating the lining of various organs, including parts of your digestive and respiratory systems. Where are goblet cells normally found? Goblet cells are typically located in the linings of your …
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In pathology, the term “rhabdoid” is used to describe tumour cells that resemble rhabdomyoblasts, which are immature skeletal muscle cells. However, these cells are not true rhabdomyoblasts and the tumours they arise in are not related to muscle tissue. Rhabdoid cells can be seen in a wide variety of tumour types and the presence of …
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